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EHT 1864

SIGMA/E1657 - ≥98% (HPLC)

Synonym: 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride

CAS Number: 754240-09-0
Empirical Formula (Hill Notation): C25H27F3N2O4S · 2HCl
Molecular Weight: 581.47
MDL Number: MFCD11114384
Linear Formula: C25H27F3N2O4S · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E1657-10MG 10 mg
 $759.00
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This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts E1657-10MG

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C25H27F3N2O4S.2ClH/c26-25(27,28)18-4-5-20-21(14-18)29-7-6-24(20)35-13-3-1-2-10-33-23-17-34-19(15-22(23)31)16-30-8-11-32-12-9-30;;/h4-7,14-15,17H,1-3,8-13,16H2;2*1H
InChI key LSECOAJFCKFQJG-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Cl.FC(F)(F)c1ccc2c(SCCCCCOC3=COC(CN4CCOCC4)=CC3=O)ccnc2c1
solubility H2O: 10 mg/mL, clear
storage temp. 2-8°C
Application: EHT 1864 has been used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity.
Biochem/physiol Actions: EHT 1864 induces dissociation of bound nucleotides. EHT 1864 induced inhibition of Rac prevents its association with downstream effectors. It is known to prevent estrogen-induced tumor cell proliferation in breast cancer.
Biochem/physiol Actions: EHT 1864 inhibits Rac function.
Biochem/physiol Actions: EHT 1864 inhibits Rac function. It prevents Aβ40 and Aβ42 production in vitro without direct inhibition of g-secretase.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the GTP Binding Proteins (Low Molecular Weight)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Legal Information: EHT 1864 compound sold under license from ExonHit Therapeutics S.A. (www.exonhit.com)
Packaging: 10 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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