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Emetine dihydrochloride

SIGMA/E2375

Synonym: 6′,7′,10,11-Tetramethoxyemetan dihydrochloride

CAS Number: 316-42-7
Empirical Formula (Hill Notation): C29H40N2O4 · 2HCl
Molecular Weight: 553.56
MDL Number: MFCD00242944
Linear Formula: C29H40N2O4 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E2375-50MG 50 mg
 $111.00
1/EA		 Add To Favorites
45-E2375-250MG 250 mg
 $467.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E2375-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E2375-500MG

 

antibiotic activity spectrum parasites
InChI 1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1
InChI key JROGBPMEKVAPEH-GXGBFOEMSA-N
mode of action protein synthesis | interferes
Quality Level 100 
SMILES string [H][C@@]12C[C@H](C[C@@]3([H])NCCC4=C3C=C(OC)C(OC)=C4)[C@@H](CC)CN1CCC5=C2C=C(OC)C(OC)=C5
storage temp. 2-8°C
Application: Emetine dihydrochloride has been used:
• as a protein synthesis inhibitor to study its effects on human papillomavirus type 8 E2 protein half-life
• to study its effects on the stress granules assembly
• as a chain-elongation inhibitor in puromycin assay for protein synthesis
Biochem/physiol Actions: Emetine dihydrochloride is a member of the ipecac alkaloids family. It can mediate inhibition of protein and nucleic acid synthesis. It exhibits antiviral activity against dengue virus infection and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Emetine dihydrochloride exhibits anti-proliferative effects against bladder cancer cells. It also possesses anti-protozoal activity.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 1, 5 g in poly bottle
Storage Temp. 2-8°C
UNSPSC 12352200

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