5′-(N-Ethylcarboxamido)adenosine

SIGMA/E2387 - powder

Synonym: NECA

CAS Number: 35920-39-9
Empirical Formula (Hill Notation): C₁₂H₁₆N₆O₄
Molecular Weight: 308.29
MDL Number: MFCD00069195
Linear Formula: C₁₂H₁₆N₆O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-E2387-50MG	50 mg	$245.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

color	white
form	powder
InChI	1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
InChI key	JADDQZYHOWSFJD-FLNNQWSLSA-N
Quality Level	200
SMILES string	CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
solubility	0.1 M HCl: 3.4 mg/mL (Solutions may be stored for several days at 4 °C.)
	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL (Solutions may be stored for several days at 4 °C.)
	DMSO: 14 mg/mL (Solutions may be stored for several days at 4 °C.)
	ethanol: soluble (Solutions may be stored for several days at 4 °C.)
	H₂O: insoluble
storage temp.	2-8°C

Application:	5′-(N-Ethylcarboxamido)adenosine has been used: • for the purification of human adenosine A_2Areceptor (A_2AR) in decylmaltoside (DM) • to determine nonspecific binding of adenosine receptors • to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay
Biochem/physiol Actions:	Potent adenosine receptor agonist with nearly equal affinity at A₁ and A₂ receptors.
Features and Benefits:	This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	5′-(N-Ethylcarboxamido)adenosine stimulates vasodilation in the pulmonary circulation through A₂-adenosine-receptor activation.
Packaging:	50 mg in poly bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264 - P301 + P310
Hazard Codes	T+
Risk Statements	28
Safety Statements	22-26-36-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352200

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