Advanced Search



(−)-Epothilone B

SIGMA/E2656 - from Sorangium cellulosum, ≥98% (HPLC)

Synonym: EPO906; EpoB; Patupilone

CAS Number: 152044-54-7
Empirical Formula (Hill Notation): C27H41NO6S
Molecular Weight: 507.68
MDL Number: MFCD02101921
Linear Formula: C27H41NO6S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E2656-1MG 1 mg
 $57.00
1/EA		 Add To Favorites
45-E2656-5MG 5 mg
 $184.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
biological source Sorangium cellulosum
color white to off-white
form lyophilized powder
InChI 1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
InChI key QXRSDHAAWVKZLJ-PVYNADRNSA-N
Quality Level 100 
SMILES string [H][C@]1(C[C@]2([H])O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)C(C)=Cc3csc(C)n3
storage condition desiccated
  protect from light
storage temp. −20°C
Biochem/physiol Actions: (-)-Epothilone B is a microtubule (MT) stabilizing drug and natural macrolide antitumor from myxobacteria Sorangium cellulosum. EpoB has similar biological properties to EpoA. However, EpoB is 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells). (-)-Epothilone B is similar to paclitaxel in binding displacement, and a substitution for paclitaxel in dependent cell growth. EpoB causes cell cycle arrest (IC50 = 3.5 nM).
Biochem/physiol Actions: EpoB is a microtubule stabilizing drug and natural macrolide antitumor.
General description: Epothilones has antimitotic properties. It prevents microtubule depolymerization and competitively blocks paclitaxel binding to microtubules. Epothilone B is used to treat metastatic breast cancer (MBC).
Packaging: 1, 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top