Estropipate

SIGMA/E2661 - ≥98% (HPLC), powder

Synonym: Estropipate; 3-(Sulfooxy)-estra-1,3,5(10)-trien-17-one : piperazine (1:1); Estrone sulfate piperazine salt; Harmogen; Ogen

CAS Number: 7280-37-7
Empirical Formula (Hill Notation): C₁₈H₂₂O₅S·C₄H₁₀N₂
Molecular Weight: 436.56
EC Number: 230-696-3
MDL Number: MFCD00867399
Linear Formula: C₁₈H₂₂O₅S·C₄H₁₀N₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-E2661-5MG	5 mg	$124.00 1/EA	Add To Favorites
45-E2661-25MG	25 mg	$386.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1
InChI key	HZEQBCVBILBTEP-ZFINNJDLSA-N
optical activity	[α]/D 100 to 120°, c = 1 in DMSO
originator	Johnson & Johnson
Quality Level	100
SMILES string	C1CNCCN1.C[C@]23CC[C@H]4[C@@H](CCc5cc(OS(O)(=O)=O)ccc45)[C@@H]2CCC3=O
solubility	DMSO: ≥24 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	Estropipate is the piperazine salt of the estrogen receptor agonist estrone-3-sulfate and a potent, specific inhibitor of the organic anion transporting polypeptide 1B1 (OATP1B1, IC₅₀ = 60 nM).
Biochem/physiol Actions:	Estropipate is the piperazine salt of the estrogen receptor agonist estrone-3-sulfate and a potent, specific inhibitor of the organic anion transporting polypeptide 1B1.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H302 - H350
Precautionary statements	P201 - P301 + P312 + P330 - P308 + P313
Hazard Codes	T
Risk Statements	45-22
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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