Anti-Endothelin Receptor B antibody produced in rabbit
SIGMA/E2764 - affinity isolated antibody, lyophilized powder
Synonym: Anti-ET-B; Anti-ET-Specific Endothelin Receptor
MDL Number: MFCD02677992
Product Type: Chemical
Immunohistochemistry Anti-Endothelin Receptor B: Cat. No. E2764: Immunohistochemical staining of paraffin embedded section of Rat lung using Anti-Endothelin Receptor B antibody (1:100). ET-B is expressed both in respiratory epithelium (black arrows) and in respiratory smooth muscle (red arrows). Note that vascular smooth muscle is not stained (blue arrows). Hematoxilin is used as the counterstain.
Immunohistochemistry Anti-Endothelin Receptor B: Cat. No. E2764: Immunohistochemical staining of Rat dorsal peri-ventricular thalamus using Anti-Endothelin Receptor B antibody. Cresyl violet is used as the counterstain.
Immunoblotting Anti-Endothelin Receptor B: Cat. No. E2764: Western blot analysis of Rat brain membranes. Lanes 1. Anti-Endothelin Receptor B antibody, (1:200). 2. Anti-Endothelin Receptor B antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 |
| western blot (chemiluminescent): 1:200 | |
| UniProt accession no. | P21451  |
| Application: | Anti-Endothelin Receptor B antibody produced in rabbit has been used in immunohistochemistry (1:100). |
| Biochem/physiol Actions: | EDNRB Endothelin receptor type B (ETB) plays a pivotal role in oesophageal cancer and may act as a therapeutic target for this intractable malignancy. It has a novel role in oligodendroglioma proliferation and acts as a potential therapeutic alternative for oligodendrogliomas. Lower expression of ETB receptor responsiveness is associated with polycystic ovary syndrome (PCOS) and may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity. |
| Biochem/physiol Actions: | Mutations in the EDNRB gene are associated with Hirschsprung disease. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Endothelin Receptor B (EDNRB) is a G-protein coupled receptor and that consists of seven transmembrane domains. EDNRB gene is located on the human chromosome at 13q22.3. |
| Immunogen: | synthetic peptide corresponding to amino acids 298-313 of rat endothelin receptor type B. The epitope is identical in all known vertebrate ET-B receptors |
| Physical form: | Lyophilized at 0.8 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 - H412 |
| Precautionary statements | P273 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 21/22-36/37/38-52/53 |
| Safety Statements | 22-26-36/37-60 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |