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3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene

SIGMA/E3145 - ≥90%

Synonym: NOC-12

CAS Number: 146724-89-2
Empirical Formula (Hill Notation): C6H16N4O2
Molecular Weight: 176.22
MDL Number: MFCD00674898
Linear Formula: C6H16N4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E3145-10MG 10 mg
 $257.00
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assay ≥90%
InChI 1S/C6H16N4O2/c1-3-7-5-6-9(4-2)10(12)8-11/h7,11H,3-6H2,1-2H3/b10-8-
InChI key DPKCLDSTXVCYSN-NTMALXAHSA-N
Quality Level 200 
SMILES string CCNCCN(CC)[N+]([O-])=NO
storage temp. −20°C
Application: 3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as nitric oxide (NO) donor to study its effects on the isolated trachea preparations from control and ovalbumin-sensitized guinea pigs in vitro. It has also been used as a NO-releasing substance to study its effects on the body contractions patterns of Tethya wilhelma.
Biochem/physiol Actions: 3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC12) liberates nitric oxide (NO) without the use of cofactors or enzymes and the formation of hazardous metabolites. A low dose of NOC12 protects astrocytes from reperfusion injury via a cyclic guanosine monophosphate (cGMP) signal. Higher dosages of NOC12 aggravates reperfusion damage through a cyclic guanosine monophosphate (cGMP)-independent mechanism.
General description: 3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC12) is a donor of nitric oxide (NO). It has a long half-life of 327 minutes.
Purity ≥90%
Storage Temp. −20°C
UNSPSC 12352200

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