Ebselen

SIGMA/E3520 - cysteine modifier

Synonym: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one

CAS Number: 60940-34-3
Empirical Formula (Hill Notation): C₁₃H₉NOSe
Molecular Weight: 274.18
MDL Number: MFCD00210937
Linear Formula: C₁₃H₉NOSe
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-E3520-25MG	25 mg	$272.00 1/EA	Add To Favorites
45-E3520-100MG	100 mg	$822.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E3520-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (TLC)
form	powder
InChI	1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChI key	DYEFUKCXAQOFHX-UHFFFAOYSA-N
mp	176-182 °C
Quality Level	200
SMILES string	O=C1N([Se]c2ccccc12)c3ccccc3
solubility	chloroform: 19.60-20.40 mg/mL, clear, yellow
storage temp.	2-8°C

Application:	Ebselen has been used as a: • voltage-dependent calcium channels (VDCCs) blocker • glutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouse extensor digitorum longus (fast-twitch) muscle • glucocerebrosidase inhibitor • hepatitis C virus helicase inhibitor
Biochem/physiol Actions:	An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol. Inhibits oxidation of low density lipoproteins (LDL).
Biochem/physiol Actions:	Ebselen, a glutathione-peroxidase-mimic, elicits anti-inflammatory activity. It also has anti-atherosclerotic functionality. Ebselen displays antibacterial action on) multidrug-resistant Staphylococcus aureus (MRSA) infections and could be a potential therapeutic target for treating MRSA based skin infection. It is regarded as neuroprotective agent and elicits chemopreventive functionality in inflammation-associated carcinogenesis.
General description:	Ebselen is a sympathomimetic amine.
Packaging:	100 mg in glass bottle
Packaging:	25 mg in poly bottle

Symbol	GHS06,GHS08,GHS09
Signal word	Danger
Hazard statements	H301 + H331 - H373 - H410
Precautionary statements	P260 - P264 - P273 - P301 + P310 - P304 + P340 + P311 - P314
Hazard Codes	T,N
Risk Statements	23/25-33-50/53
Safety Statements	20/21-28-45-60-61
RIDADR	UN 3283 6.1 / PGIII
WGK Germany	WGK 3

Purity	≥98% (TLC)
mp	176-182 °C
Storage Temp.	2-8°C
UNSPSC	12352202

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