[D-Pen^2,5]-Enkephalin hydrate

SIGMA/E3888 - ≥95% (HPLC)

Synonym: DPDPE

Empirical Formula (Hill Notation): C₃₀H₃₉N₅O₇S₂ · xH₂O
Molecular Weight: 645.79 (anhydrous basis)
MDL Number: MFCD00076430
Linear Formula: C₃₀H₃₉N₅O₇S₂ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-E3888-1MG	1 mg	$174.00 1/EA		Add To Favorites
45-E3888-5MG	5 mg	$734.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
InChI	1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1
InChI key	MCMMCRYPQBNCPH-WMIMKTLMSA-N
Quality Level	200
SMILES string	CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H]1C(O)=O
storage temp.	−20°C

Amino Acid Sequence:	Tyr-Pen-Gly-Phe-Pen [Disulfide Bridge: 2-5]
Application:	[D-Pen^2,5]-Enkephalin hydrate (DPDPE) has been used to study the pharmacodynamic and pharmacokinetic capabilities of polyethylene glycol (PEG) conjugate of DPDPE in rodents. It has been used to study the tendency of opiate self-administration in male Long-Evans rats, in ventral tegmental area (VTA).
Biochem/physiol Actions:	Antinociceptive activity mediated through the δ₁ receptor while the modulatory activity is mediated through the δ₂ receptor. Tritiated [D-Pen^2,5]-enkephalin is used as a δ₁ ligand.
General description:	[D-Pen^2,5]-Enkephalin hydrate, also called DPDPE, is a peptide and acts as a δ1-opioid receptor agonist. Opioid receptors are divided into three types called, μ, κ and δ, depending upon their ligands. These ligands are peptides and are classified as enkephalins, endorphins and dynorphins.
Other Notes:	Lyophilized from 0.1% TFA in H2O
Packaging:	1, 5 mg in serum bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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