β-Estradiol-Water Soluble

SIGMA/E4389 - BioReagent, suitable for cell culture

Synonym: Cyclodextrin-encapsulated 17β-estradiol

MDL Number: MFCD00133134
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-E4389-100MG	100 mg	$214.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

biological source	synthetic (organic)
form	powder
InChI	1S/C46H78O35.C18H24O2/c1-12-20(55)40-68-13(5-48)32(12)75-41-26(61)25(60)37(18(10-53)69-41)81-46-39(67-4-2-3-47)31(66)38(19(11-54)74-46)80-45-30(65)24(59)36(17(9-52)73-45)79-44-29(64)23(58)35(16(8-51)72-44)78-43-28(63)22(57)34(15(7-50)71-43)77-42-27(62)21(56)33(76-40)14(6-49)70-42;1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h12-66H,2-11H2,1H3;3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31+,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-;14-,15-,16+,17+,18+/m11/s1
InChI key	XMURHKLFGRLVRW-JKDYGSMVSA-N
product line	BioReagent
Quality Level	200
shipped in	ambient
SMILES string	C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CC[C@@H]2O.C[C@@H]5[C@@H](O)[C@@H]6O[C@H](CO)[C@H]5O[C@H]7O[C@H](CO)[C@@H](O[C@H]8O[C@H](CO)[C@@H](O[C@H]9O[C@H](CO)[C@@H](O[C@H]%10O[C@H](CO)[C@@H](O[C@H]%11O[C@H](CO)[C@@H](O[C@H]%12O[C@H](CO)[C@@H](O6)[C@H](O)[C@H]%12O)[C@H](O)[C@H]%11O)[C@H](O)[C@H]%10O)[C@H](O)[C@H]9O)[C@H](O)[C@H]8OCCCO)[C@H](O)[C@H]7O
solubility	H₂O: 25 mg/mL, clear to slightly hazy
sterility	non-sterile
storage temp.	room temp
technique(s)	cell culture \| mammalian: suitable

Application:	β-estradiol has been used: • to culture differentiated adipocytes • for estradiol treatment in rats • for oocyte maturation in vitro β-Estradiol is used to study cell differentiation and transformations (tumorigenicity). This product is not recommended for use in binding assays.
General description:	β-estradiol is a natural human estrogen. It is vital for the growth of breast and reproductive epithelia, maturation of long bones and development of secondary sexual characteristics. Estradiol is produced by immature germ cells, spermatozoa, Leydig cells and Sertoli cells. β-estradiol acts as a menopausal hormones. It is involved in replacement therapy for female hypogonadism or primary ovarian failure. Reduced levels of β-estradiol are linked to heart disease and osteoporosis. Estradiol plays a critical role in proliferation, modulation of ion transport and control of apoptosis in Sertoli cells. It maintains sperm concentration, motility and morphology.
Other Notes:	Contains 40-55 mg estradiol per gram of solid; balance 2-hydroxypropyl-β-cyclodextrin.
Packaging:	100 mg in poly bottle
Packaging:	Package size based on estradiol

Symbol	GHS08,GHS09
Signal word	Danger
Hazard statements	H351 - H360FD - H362 - H411
Precautionary statements	P202 - P260 - P263 - P264 - P273 - P308 + P313
Hazard Codes	T
Risk Statements	60-63-40-64
Safety Statements	53-36/37-45
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3

Storage Temp.	room temp
UNSPSC	12352209

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