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Ethambutol dihydrochloride

SIGMA/E4630 - antimycobacterial

Synonym: Ethambutol; Ethambutol HCL; 2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride; Emb

CAS Number: 1070-11-7
Empirical Formula (Hill Notation): C10H24N2O2 · 2HCl
Molecular Weight: 277.23
EC Number: 213-970-7
MDL Number: MFCD21364080
Linear Formula: C10H24N2O2 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E4630-25G 25 g
 $192.00
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45-E4630-100G 100 g
 $638.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: E4630-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: E4630-100G

 

antibiotic activity spectrum mycobacteria
color white
form powder
InChI 1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
InChI key AUAHHJJRFHRVPV-BZDVOYDHSA-N
mode of action cell wall synthesis | interferes
optical activity [α]25/D 6.0 to 6.7°, c = 10 in water
Quality Level 200 
SMILES string CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl
solubility H2O: 50 mg/mL
Application: Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance.
Application: Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China.
Biochem/physiol Actions: Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.
Biochem/physiol Actions: Ethambutol specifically inhibits arabinosyltransferases in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria.
Packaging: 25, 100 g in poly bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P264 - P270 - P301 + P312 - P501
Hazard Codes T
Risk Statements 61
Safety Statements 53-22-36/37/39-45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 51281511

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