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Anti-LPA1, C-Terminal antibody produced in rabbit

SIGMA/E5017 - IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-EDG-2; Anti-Endothelial Cell Differentiation Gene 2

MDL Number: MFCD02686119
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E5017-.1MG 0.1 mg
 $1210.00
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antibody form IgG fraction of antiserum
antibody product type primary antibodies
biological source rabbit
clone polyclonal
conjugate unconjugated
form buffered aqueous solution
mol wt antigen ~50 kDa
Quality Level 200 
shipped in dry ice
species reactivity human, rat
storage temp. −20°C
target post-translational modification unmodified
technique(s) western blot: suitable
UniProt accession no. Q92633 
Application: Anti-LPA1, C-Terminal antibody produced in rabbit is suitable for western blotting at a working dilution of 1:1000 using rat brain microsomal fraction.
Biochem/physiol Actions: Lysophosphatidic acid receptor 1 (LPA1) is a protein encoded by the LPAR1 gene in humans. It is constitutively localized in the nucleus of mammalian cells and may be involved in regulating intranuclear protein phosphorylation and signalling. LPA1 is differentially expressed in androgen-insensitive and LPA-responsive cells. It is not expressed in androgen-dependent and LPA-resistant cells.Its expression is significantly higher in the cancer compared with the benign tissues and may possibly act as a drug target to interfere with progression of prostate cancer. LPA1 helps in promoting cell proliferation, survival and migration by acting on cognate G protein-coupled receptors.
Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen: synthetic peptide corresponding to amino acids 328-344 of human EDG-2/LPA1.
Physical form: Solution in PBS with 0.08% sodium azide
Storage Temp. −20°C
UNSPSC 12352203

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