Enniatin B1
SIGMA/E5286 - from Gnomonia errabunda, ≥95% (HPLC)
Synonym: 2-
CAS Number: 19914-20-6
Empirical Formula (Hill Notation): C34H59N3O9
Molecular Weight: 653.85
MDL Number: MFCD14635386
Linear Formula: C34H59N3O9
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| biological source | Gnomonia errabunda |
| InChI | 1S/C34H59N3O9/c1-16-22(12 |
| InChI key | UQCSETXJXJTMKO-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | N1(C(C(=O)OC(C(=O)N(C(C(= |
| solubility | DMSO: 10 mg/mL |
| ethanol: 10 mg/mL | |
| methanol: 10 mg/mL | |
| storage temp. | −20°C |
| Application: | Enniatin B1 has been used as a mycotoxin in the cell viability assay of primary porcine brain capillary endothelial cells (PBCEC) and human brain microvascular capillary cells (HBMEC). It has also been used as an analytical standard in mass spectrometry measurements. |
| Biochem/physiol Actions: | Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42). Enniatins B and B1 inhibit the multi-drug resistance transporter Pdr5p from Saccharomyces cerevisiae, indicating their beneficial potential in cases of drug resistant patients. |
| Biochem/physiol Actions: | Enniatins are cyclohexadepsipeptide mycotoxins that have phytotoxic, antibiotic, and insecticidal activities and function as ionophors. |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 + H311 + H331 |
| Precautionary statements | P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311 |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 45 |
| RIDADR | UN 3462 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |