Pioglitazone hydrochloride
SIGMA/E6910 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 112529-15-4
Empirical Formula (Hill Notation): C19H20N2O3S · HCl
Molecular Weight: 392.90
MDL Number: MFCD04975446
Linear Formula: C19H20N2O3S · HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C19H20N2O3S.ClH/c1-2-1 |
| InChI key | GHUUBYQTCDQWRA-UHFFFAOYSA |
| originator | Takeda |
| Quality Level | 100  |
| SMILES string | Cl.CCc1ccc(CCOc2ccc(CC3SC |
| solubility | DMSO: ≥10 mg/mL |
| storage temp. | room temp |
| Application: | Pioglitazone hydrochloride has been used: • to administer to mice model and treated the hepatoma cell line to study its effect on regulating insulin-degrading enzyme (IDE) in diet-induced obese (DIO) C57BL/6 mice • in drug preparation to analyze its effects on shortening and calcium transport in ventricular myocytes from the Goto-Kakizaki (GK) type 2 diabetic rat • to treat HepG2 cells with peroxisome proliferator-activated receptor γ (PPARγ) agonists to examine its effect on TOMM40-, APOE- and APOC1-mRNA levels |
| Biochem/physiol Actions: | Pioglitazone hydrochloride is a PPARγ agonist and thiazolidinedione (TZD) anti-diabetic. |
| Biochem/physiol Actions: | Pioglitazone hydrochloride is a PPARγ agonist and thiazolidinedione (TZD) anti-diabetic. Pioglitazone is a selective agonist of the nuclear receptor peroxisome proliferator-activated receptor γ (PPAR-γ) and to a lesser extent PPAR-α. |
| Biochem/physiol Actions: | Pioglitazone hydrochloride is usually used to treat type-II diabetes. It has the ability to block hepatic gluconeogenesis. |
| Features and Benefits: | This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the AMPKs and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Takeda . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | Pioglitazone hydrochloride consists of poly-morphs, form I and form II. It is an oral antidiabetic agent, that is a member of the thiazolidinedione group. |
| Packaging: | 10, 50 mg in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 41106305 |