Elafin human
SIGMA/E7280 - >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae
Synonym: Elastase-specific inhibitor; skin-derived antileukoprotease
MDL Number: MFCD00146824
Product Type: Chemical
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| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| assay | >90% (by MS, HPLC and SDS-PAGE) |
| form | powder |
| mode of action | enzyme | inhibits |
| mol wt | ~6 kDa |
| potency | 1.7 x 10-10 M Ki (human leukocyte elastase) |
| 4.2 x 10-10 M Ki (human proteinase 3) | |
| Quality Level | 200  |
| recombinant | expressed in Saccharomyces cerevisiae |
| shipped in | ambient |
| storage temp. | −20°C |
| UniProt accession no. | P19957  |
| Biochem/physiol Actions: | Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria. |
| Biochem/physiol Actions: | Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. |
| Biochem/physiol Actions: | Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions. |
| General description: | Chemical structure: peptide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >90% (by MS, HPLC and SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |