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Erastin

SIGMA/E7781 - ≥98% (HPLC)

Synonym: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone

CAS Number: 571203-78-6
Empirical Formula (Hill Notation): C30H31ClN4O4
Molecular Weight: 547.04
MDL Number: MFCD09837984
Linear Formula: C30H31ClN4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E7781-5MG 5 mg
 $0.00
1/EA
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E7781-1MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E7781-5MG

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
InChI key BKQFRNYHFIQEKN-UHFFFAOYSA-N
SMILES string CCOc1ccccc1N2C(=O)c3ccccc3N=C2C(C)N4CCN(CC4)C(=O)COc5ccc(Cl)cc5
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. −20°C
Application: Erastin has been used:
• as a positive control for inducing ferroptosis in hepatic stellate cell (HSC)
• to induce ferroptosis and in transferrin internalization assay of human fibrosarcoma HT1080 cells
• to induce ferroptosis of muscle-derived cell lines
Biochem/physiol Actions: Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces ferroptosis, a non-apoptotic tumor cell death, by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death.
Biochem/physiol Actions: Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc-.
Packaging: 1, 5 mg in glass bottle
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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