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Emodin

SIGMA/E7881 - from Frangula bark, ≥90% (HPLC)

Synonym: 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione; 1,3,8-Tri­hydroxy-6-methyl­anthra­quinone; 6-Methyl-1,3,8-tri­hydroxy­anthra­quinone; Archin; Emodol; Frangula-emodin; Frangulic acid; Rheum emodin

CAS Number: 518-82-1
Empirical Formula (Hill Notation): C15H10O5
Molecular Weight: 270.24
EC Number: 208-258-8
MDL Number: MFCD00001207
Linear Formula: C15H10O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E7881-50MG 50 mg
 $148.00
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45-E7881-250MG 250 mg
 $483.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E7881-50MG.
ATR-IR Spectra for Emodin.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E7881-250MG

 

assay ≥90% (HPLC)
biological source Frangula bark
InChI 1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
InChI key RHMXXJGYXNZAPX-UHFFFAOYSA-N
Quality Level 200 
SMILES string Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
solubility aqueous base: soluble
  DMSO: soluble
  ethanol: soluble
storage temp. 2-8°C
Application: Emodin has been used:
• to investigate its regulatory mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury in myocarditis
• as a reference standard for the development and validation of high performance liquid chromatography (HPLC)-photodiode array (PDA) assay method
• to inhibit Tau aggregation
• for direct binding assay
Biochem/physiol Actions: Inhibitor of NF-κB activation and adhesion molecule expression. Casein Kinase 2 (CK2) inhibitor.
General description: Emodin is an anthraquinone derivative, extracted from rhubarb (Rheum palmatum). It has antibacterial, anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. Emodin exhibits cytotoxic effects, apoptosis and stimulates the expression of hypoxia-inducible factor 1α, glutathione S-transferase P and N-acetyltransferase. It prevents the growth of prostate cancer cells. Emodin is used to treat constipation and hemorrhoid. It displays immunosuppressive and anti-diabetic effects.
Packaging: 250 mg in poly bottle
Packaging: 50 mg in glass insert
Purity ≥90% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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