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Equilin

SIGMA/E8126

Synonym: 1,3,5(10),7-Estratetraen-3-ol-17-one; 3-Hydroxy-1,3,5(10),7-estratetraen-17-one; 7-Dehydroestrone

CAS Number: 474-86-2
Empirical Formula (Hill Notation): C18H20O2
Molecular Weight: 268.35
EC Number: 207-488-6
MDL Number: MFCD00046223
Linear Formula: C18H20O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E8126-100MG 100 mg
 $173.00
1/EA		 Add To Favorites
45-E8126-1G 1 g
 $1060.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E8126-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E8126-1G

 

assay ≥98% (HPLC)
biological source synthetic (organic)
form powder
InChI 1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16,19H,2,6-9H2,1H3/t14-,16+,18+/m1/s1
InChI key WKRLQDKEXYKHJB-HFTRVMKXSA-N
mp 238-240 °C (lit.)
Quality Level 100 
shipped in ambient
SMILES string C[C@]12CC[C@H]3C(=CCc4cc(O)ccc34)[C@@H]1CCC2=O
solubility chloroform: methanol (1:1): 40 mg/mL, clear, colorless to faintly yellow
sterility non-sterile
storage temp. room temp
technique(s) inhibition assay: suitable
Biochem/physiol Actions: Equilin is the Mare estrogen and is majorly used in multi-estrogen drugs for hormone replacement therapy. It is synthesized in the microsomes of mare placenta. It mediates estrogen receptor β (ERβ) expression resulting in the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) which favors monocytes adhesion in atherosclerosis. In vitro equilin inhibits 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that catalyzes the conversion of estrone to 17β-estradiol.
Packaging: 1 g in poly bottle
Packaging: 100 mg in poly bottle
Purity ≥98% (HPLC)
mp 238-240 °C (lit.)
Storage Temp. room temp
UNSPSC 12352200

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