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Exo 1

SIGMA/E8280 - ≥98% (HPLC), solid

Synonym: 2-(4-Fluorobenzoylamino)benzoic acid methyl ester; 2-(4-Fluorobenzoylamino)methylbenzoate

CAS Number: 75541-83-2
Empirical Formula (Hill Notation): C15H12NFO3
Molecular Weight: 273.26
MDL Number: MFCD00028104
Linear Formula: C15H12NFO3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E8280-5MG 5 mg
 $60.50
1/EA		 Add To Favorites
45-E8280-25MG 25 mg
 $213.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form solid
InChI 1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)
InChI key KIAPWMKFHIKQOZ-UHFFFAOYSA-N
Quality Level 100 
SMILES string COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2
solubility DMSO: soluble 19 mg/mL
Application: Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the long interspersed nuclear element-1 (L1) retrotransposition.
Biochem/physiol Actions: Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.
Biochem/physiol Actions: Reversible inhibitor of exocytosis; Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352203

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