(E/Z)-Endoxifen Hydrochloride Hydrate

SIGMA/E8284 - ≥98% (HPLC)

Synonym: (E/Z)-Endoxifen hydrochloride hydrate; (E/Z)-4-Hydroxy-N-desmethyltamoxifen hydrochloride hydrate; (E/Z)-4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol hydrochloride hydrate (1:1 E/Z mixture); (E/Z)-4OHNDtam hydrochloride hydrate

Empirical Formula (Hill Notation): C₂₅H₂₇NO₂ · HCl · xH₂O
Molecular Weight: 409.95 (anhydrous basis)
MDL Number: MFCD16875406
Linear Formula: C₂₅H₂₇NO₂ · HCl · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-E8284-5MG	5 mg	$153.00 1/EA	Add To Favorites
45-E8284-25MG	25 mg	$578.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	solid
InChI	1S/C25H27NO2.ClH.H2O/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2;;/h4-16,26-27H,3,17-18H2,1-2H3;1H;1H2/b25-24-;;
InChI key	BISAMGUAXFFKDX-NDIQBZANSA-N
Quality Level	100
SMILES string	O.Cl.CCC(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCNC)cc3
solubility	DMSO: >10 mg/mL
storage condition	desiccated
storage temp.	2-8°C

Application:	(E/Z)-Endoxifen Hydrochloride Hydrate has been used: as a selective estrogen receptor modulator (SERM) to study the role of miR-27a expression to impregnate a biocompatible polymer in the subcutaneous space adjacent to the TA muscle of PDGFRαCreER;R26NG mice to study its in vivo performance and properties for CreERT2 (mutant estrogen receptor) control
Biochem/physiol Actions:	(E/Z)-Endoxifen hydrochloride ((E/Z)-4-Hydroxy-N-desmethyltamoxifen hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). It is equipotent to 4-hydroxytamoxifen with respect to estrogen receptor binding and inhibition of 17-estradiol (E2)-induced cell proliferation. It is primarily catalyzed by cytochrome P450 2D6 (CYP2D6). Mutations in CYP2D6 may prevent response to tamoxifen by preventing formation of endoxifen. The gene expression patterns of five genes have been validated to be differentially regulated by endoxifen and 4-OH-Tamoxifen. Endoxifen and 4-OH-Tam have similar effects on global gene expression patterns in MCF-7 cells and the majority of the affected genes are estrogen-regulated genes.
Biochem/physiol Actions:	(E/Z)-endoxifen hydrochloride may be used in hormone therapy to fight breast cancer. Endoxifen is considered as an active metabolite of tamoxifen. Hence it is responsible for the tamoxifen activity in the human body.
Biochem/physiol Actions:	Tamoxifen metabolite; Selective Estrogen response modifier (SERM) .
Features and Benefits:	This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	nwg
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352203

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