E3330
SIGMA/E8534 - ≥98% (HPLC)
Synonym: (2E)
CAS Number: 136164-66-4
Empirical Formula (Hill Notation): C21H30O6
Molecular Weight: 378.46
MDL Number: MFCD00901331
Linear Formula: C21H30O6
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts E8534-5MG
| assay | ≥98% (HPLC) |
| color | red to orange |
| form | powder |
| InChI | 1S/C21H30O6/c1-5-6-7-8-9- |
| InChI key | AALSSIXXBDPENJ-FYWRMAATSA |
| Quality Level | 100  |
| SMILES string | CCCCCCCCCC(=C/C1=C(C)C(= |
| solubility | DMSO: >20 mg/mL |
| storage temp. | 2-8°C |
| Application: | E3330 has been used in the inhibition of endothelial cancer cells and apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1). |
| Biochem/physiol Actions: | E3330 is a specific inhibitor of AP endonuclease 1 redox domain. E3330 inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity. AP endonuclease 1 (APE1; also known as REF-1) is a multifunctional protein with dual functions in DNA repair and redox regulation of transcription factors. It is involved in apurinic/apyrimidinic endonuclease DNA base excision repair activity, in proofreading exonuclease activity, and in modulating DNA binding activity of several transcription factors including NF-κB, Egr-1, p53, AP-1, CREB, HIF-α, and members of the Pax family. APE1 is overexpressed in several human cancers, and disruption of APE1 function has detrimental effects on cancer cell viability. E3330 significantly reduces the growth of human pancreatic cancer cells in vitro and inhibits pancreatic cancer cell migration. |
| Biochem/physiol Actions: | E3330 is a specific inhibitor of AP endonuclease 1 redox domain; inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard statements | H413 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |