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E3330

SIGMA/E8534 - ≥98% (HPLC)

Synonym: (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid

CAS Number: 136164-66-4
Empirical Formula (Hill Notation): C21H30O6
Molecular Weight: 378.46
MDL Number: MFCD00901331
Linear Formula: C21H30O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E8534-5MG 5 mg
 $364.00
1/EA		 Add To Favorites
45-E8534-25MG 25 mg
 $981.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color red to orange
form powder
InChI 1S/C21H30O6/c1-5-6-7-8-9-10-11-12-15(21(24)25)13-16-14(2)17(22)19(26-3)20(27-4)18(16)23/h13H,5-12H2,1-4H3,(H,24,25)/b15-13+
InChI key AALSSIXXBDPENJ-FYWRMAATSA-N
Quality Level 100 
SMILES string CCCCCCCCCC(=C/C1=C(C)C(=O)C(OC)=C(OC)C1=O)C(O)=O
solubility DMSO: >20 mg/mL
storage temp. 2-8°C
Application: E3330 has been used in the inhibition of endothelial cancer cells and apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1).
Biochem/physiol Actions: E3330 is a specific inhibitor of AP endonuclease 1 redox domain. E3330 inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity. AP endonuclease 1 (APE1; also known as REF-1) is a multifunctional protein with dual functions in DNA repair and redox regulation of transcription factors. It is involved in apurinic/apyrimidinic endonuclease DNA base excision repair activity, in proofreading exonuclease activity, and in modulating DNA binding activity of several transcription factors including NF-κB, Egr-1, p53, AP-1, CREB, HIF-α, and members of the Pax family. APE1 is overexpressed in several human cancers, and disruption of APE1 function has detrimental effects on cancer cell viability. E3330 significantly reduces the growth of human pancreatic cancer cells in vitro and inhibits pancreatic cancer cell migration.
Biochem/physiol Actions: E3330 is a specific inhibitor of AP endonuclease 1 redox domain; inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity.
Packaging: 5, 25 mg in glass bottle
Hazard statements H413
RIDADR NONH for all modes of transport
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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