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E-64d

SIGMA/E8640 - protease inhibitor

Synonym: (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester; EST

CAS Number: 88321-09-9
Empirical Formula (Hill Notation): C17H30N2O5
Molecular Weight: 342.43
MDL Number: MFCD00132883
Linear Formula: C17H30N2O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E8640-250UG 250 µg
 $156.00
1/EA		 Add To Favorites
45-E8640-1MG 1 mg
 $397.00
1/EA		 Add To Favorites

 

assay ≥98% (TLC)
biological source synthetic (organic)
form powder
InChI 1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
InChI key SRVFFFJZQVENJC-IHRRRGAJSA-N
Quality Level 200 
SMILES string CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
solubility methanol: water (1:1): 5 mg/mL, clear, colorless
storage temp. −20°C
Application: E-64d has been used as a lysosomal inhibitor in human acute promyelocytic leukemia NB4 cells and Huh-7 cells. It has also been used as a protease inhibitor in free calcium physiological tyrode solution for perfusion into the isolated heart samples.
Biochem/physiol Actions: E-64d is an epoxysuccinyl peptide and an inhibitor of cysteine protease cathepsin B, calpains 1 and 2. E-64d by its cathepsin B protease inhibition functionality, may serve as a potential drug for treating traumatic brain injury (TBI) and Alzheimer′s disease (AD). It inhibits gametocyte surface antigen resulting in a decreased oocyst production in Plasmodium falciparum.
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (TLC)
Storage Temp. −20°C
UNSPSC 12352202

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