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Epirubicin hydrochloride

SIGMA/E9406 - ≥90% (HPLC)

Synonym: 4′-Epidoxorubicin hydrochloride; Epidoxorubicin hydrochloride

CAS Number: 56390-09-1
Empirical Formula (Hill Notation): C27H29NO11 · HCl
Molecular Weight: 579.98
EC Number: 260-145-2
MDL Number: MFCD00941448
Linear Formula: C27H29NO11 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E9406-5MG 5 mg
 $223.00
1/EA		 Add To Favorites
45-E9406-10MG 10 mg
 $0.00
1/EA
CALL FOR PRICE		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E9406-10MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E9406-5MG

 

antibiotic activity spectrum neoplastics
assay ≥90% (HPLC)
biological source synthetic
color red to deep red
form powder
InChI 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1
InChI key MWWSFMDVAYGXBV-FGBSZODSSA-N
mode of action DNA synthesis | interferes
  enzyme | inhibits
Quality Level 100 
SMILES string Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
solubility H2O: soluble
storage temp. −20°C
Application: Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.
Biochem/physiol Actions: Cell-permeable anthracycline antitumor antibiotic. Antineoplastic. A stereoisomer of doxorubicin that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting topoisomerase II.
Biochem/physiol Actions: Epirubicin is antimitotic and cytotoxic. It inhibits nucleic acid and protein synthesis. Epirubicin may do so by forming complexes with DNA and intercalation between base pairs, by inhibiting topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, and by preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
Packaging: 5, 10 mg in glass bottle
Purity ≥90% (HPLC)
Storage Temp. −20°C
UNSPSC 51102829

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