Ebastine
SIGMA/E9531 - ≥98% (HPLC), solid
Synonym: 1-
CAS Number: 90729-43-4
Empirical Formula (Hill Notation): C32H39NO2
Molecular Weight: 469.66
MDL Number: MFCD00865661
Linear Formula: C32H39NO2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white |
| form | solid |
| InChI | 1S/C32H39NO2/c1-32(2,3)28 |
| InChI key | MJJALKDDGIKVBE-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CC(C)(C)c1ccc(cc1)C(=O)CC |
| solubility | DMSO: >10 mg/mL |
| H2O: insoluble | |
| storage temp. | room temp |
| Application: | Ebastine has been used as a cationic amphiphilic drug (CAD) in sensitizing cancerous cells to chemotherapy and revert multidrug resistance. |
| Biochem/physiol Actions: | Ebastine is a non-sedating histamine H1 receptor antagonist, which inhibits allergen-induced bronchospasm in conscious guinea pigs. Unlike other compounds in this category, ebastine does not prolong the QT interval at up to five times the recommended therapeutic dose. |
| Biochem/physiol Actions: | Ebastine is a non-sedating histamine H1 receptor antagonist. |
| Features and Benefits: | This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: | Ebastine is metabolised by cytochrome P450 3A (CYP3A4) to carebastine. It is used to treat allergic rhinitis and chronic idiopathic urticaria. |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |