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Ebastine

SIGMA/E9531 - ≥98% (HPLC), solid

Synonym: 1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone

CAS Number: 90729-43-4
Empirical Formula (Hill Notation): C32H39NO2
Molecular Weight: 469.66
MDL Number: MFCD00865661
Linear Formula: C32H39NO2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E9531-10MG 10 mg
 $264.00
1/EA		 Add To Favorites
45-E9531-50MG 50 mg
 $790.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form solid
InChI 1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
InChI key MJJALKDDGIKVBE-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC(C)(C)c1ccc(cc1)C(=O)CCCN2CCC(CC2)OC(c3ccccc3)c4ccccc4
solubility DMSO: >10 mg/mL
  H2O: insoluble
storage temp. room temp
Application: Ebastine has been used as a cationic amphiphilic drug (CAD) in sensitizing cancerous cells to chemotherapy and revert multidrug resistance.
Biochem/physiol Actions: Ebastine is a non-sedating histamine H1 receptor antagonist, which inhibits allergen-induced bronchospasm in conscious guinea pigs. Unlike other compounds in this category, ebastine does not prolong the QT interval at up to five times the recommended therapeutic dose.
Biochem/physiol Actions: Ebastine is a non-sedating histamine H1 receptor antagonist.
Features and Benefits: This compound is featured on the Histamine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Ebastine is metabolised by cytochrome P450 3A (CYP3A4) to carebastine. It is used to treat allergic rhinitis and chronic idiopathic urticaria.
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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