Estrone

SIGMA/E9750 - ≥99%

Synonym: 1,3,5(10)-Estratrien-3-ol-17-one; 3-Hydroxy-1,3,5(10)-estratrien-17-one; Folliculin

CAS Number: 53-16-7
Empirical Formula (Hill Notation): C₁₈H₂₂O₂
Molecular Weight: 270.37
EC Number: 200-164-5
MDL Number: MFCD00003620
Linear Formula: C₁₈H₂₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-E9750-500MG	500 mg	$34.00 1/EA	Add To Favorites
45-E9750-1G	1 g	$48.20 1/EA	Add To Favorites
45-E9750-5G	5 g	$181.00 1/EA	Add To Favorites
45-E9750-25G	25 g	$611.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E9750-5G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99%
biological source	synthetic (organic)
form	powder
InChI	1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
InChI key	DNXHEGUUPJUMQT-CBZIJGRNSA-N
mp	258-260 °C (lit.)
Quality Level	200
shipped in	ambient
SMILES string	C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O
solubility	dioxane: 50 mg/mL, clear, colorless to very faintly yellow
sterility	non-sterile
storage temp.	room temp

Application:	Estrone has been used: • as medium supplement for hormone based degranulation studies of natural killer cells • as an endocrine disrupting compound for screening bacterial biosensor in toxic water. • as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines
Biochem/physiol Actions:	Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.
Packaging:	1, 5, 25 g in glass bottle
Packaging:	500 mg in glass bottle

Symbol	GHS08
Signal word	Danger
Hazard statements	H351 - H360FD - H362
Precautionary statements	P202 - P260 - P263 - P264 - P270 - P308 + P313
Hazard Codes	T
Risk Statements	60-63-40-64
Safety Statements	53-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99%
mp	258-260 °C (lit.)
Storage Temp.	room temp
UNSPSC	51111800

To Order From a Quote