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Estrone

SIGMA/E9750 - ≥99%

Synonym: 1,3,5(10)-Estratrien-3-ol-17-one; 3-Hydroxy-1,3,5(10)-estratrien-17-one; Folliculin

CAS Number: 53-16-7
Empirical Formula (Hill Notation): C18H22O2
Molecular Weight: 270.37
EC Number: 200-164-5
MDL Number: MFCD00003620
Linear Formula: C18H22O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-E9750-500MG 500 mg
 $31.70
1/EA		 Add To Favorites
45-E9750-1G 1 g
 $44.90
1/EA		 Add To Favorites
45-E9750-5G 5 g
 $169.00
1/EA		 Add To Favorites
45-E9750-25G 25 g
 $570.00
1/EA		 Add To Favorites

 

assay ≥99%
biological source synthetic (organic)
form powder
InChI 1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
InChI key DNXHEGUUPJUMQT-CBZIJGRNSA-N
mp 258-260 °C (lit.)
Quality Level 200 
shipped in ambient
SMILES string C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O
solubility dioxane: 50 mg/mL, clear, colorless to very faintly yellow
sterility non-sterile
storage temp. room temp
Application: Estrone has been used:
•  as medium supplement for hormone based degranulation studies of natural killer cells
•  as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
•  as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines
Biochem/physiol Actions: Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.
Features and Benefits: This compound is a featured product for ADME Tox research. Click here  to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Nuclear Receptors (Steroids)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.
Packaging: 1, 5, 25 g in glass bottle
Packaging: 500 mg in glass bottle
Purity ≥99%
mp 258-260 °C (lit.)
Storage Temp. room temp
UNSPSC 51111800

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