Furosemide
SIGMA/F4381
Synonym: 4-Chloro-N-
CAS Number: 54-31-9
Empirical Formula (Hill Notation): C12H11ClN2O5S
Molecular Weight: 330.74
EC Number: 200-203-6
MDL Number: MFCD00010549
Linear Formula: C12H11ClN2O5S
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F4381-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F4381-1G
| assay | ≥98% (HPLC) |
| biological source | synthetic (organic) |
| form | powder |
| InChI | 1S/C12H11ClN2O5S/c13-9-5- |
| InChI key | ZZUFCTLCJUWOSV-UHFFFAOYSA |
| mp | 220 °C (dec.) (lit.) |
| originator | Sanofi Aventis |
| Quality Level | 200  |
| SMILES string | NS(=O)(=O)c1cc(C(O)=O)c(N |
| solubility | acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow |
| storage temp. | room temp |
| Application: | Furosemide has been used: • to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice • to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats • as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II) |
| Biochem/physiol Actions: | "High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive. |
| Biochem/physiol Actions: | Furosemide can block the Na+/K+/2Cl- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure. |
| Biochem/physiol Actions: | Inhibits ion co-transport in the kidney. |
| Features and Benefits: | This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound was developed by Sanofi Aventis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | Furosemide is a an ototoxic high-ceiling diuretic. |
| Packaging: | 1, 5, 10, 25 g in glass bottle |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302 - H360FD |
| Precautionary statements | P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313 |
| Hazard Codes | T |
| Risk Statements | 61 |
| Safety Statements | 53-22-36/37/39-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥98% (HPLC) |
| mp | 220 °C (dec.) (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |