5-Fluoroorotic acid hydrate
SIGMA/F5013 - ≥98%
Synonym: 2,6-
CAS Number: 207291-81-4
Empirical Formula (Hill Notation): C5H3FN2O4 · xH2O
Molecular Weight: 174.09 (anhydrous basis)
EC Number: 211-876-0
MDL Number: MFCD00150658
Linear Formula: C5H3FN2O4 · xH2O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F5013-50MG.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F5013-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F5013-250MG
| assay | ≥98% |
| biological source | synthetic |
| form | powder |
| InChI | 1S/C5H3FN2O4.H2O/c6-1-2(4 |
| InChI key | LODRRYMGPWQCTR-UHFFFAOYSA |
| mp | 278 °C (dec.) (lit.) |
| Quality Level | 200  |
| SMILES string | OC(C(NC(N1)=O)=C(F)C1=O)= |
| solubility | 4 M NH4OH: 50 mg/mL, clear, colorless to light yellow |
| storage temp. | −20°C |
| technique(s) | cell culture | plant: suitable |
| Application: | 5-Fluoroorotic acid hydrate has also been used as a counter-selection agent to screen L. lactis (multi) peptidase knockout mutants and C. albicans. It has been used in synthesis of 5-fluoroorotidine 5′-monophosphate (FOMP). |
| Application: | Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae. |
| Biochem/physiol Actions: | 5-Fluoroorotic acid is a selective inhibitor of rRNA synthesis in mammals. |
| Packaging: | 1 g in poly bottle |
| Packaging: | 250 mg in poly bottle |
| Packaging: | 50 mg in glass insert |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H315 - H319 - H335 |
| Precautionary statements | P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% |
| mp | 278 °C (dec.) (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 12352204 |