5-Fluorouracil
SIGMA/F6627 - ≥99% (HPLC), powder
Synonym: 2,4-
CAS Number: 51-21-8
Empirical Formula (Hill Notation): C4H3FN2O2
Molecular Weight: 130.08
EC Number: 200-085-6
MDL Number: MFCD00006018
Linear Formula: C4H3FN2O2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F6627-10G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F6627-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F6627-5G
| εmax | 7.07 at 265 nm in 0.1 M HCl |
| application(s) | diagnostic assay manufacturing hematology histology |
| assay | ≥99% (HPLC) |
| color | white |
| form | powder |
| InChI | 1S/C4H3FN2O2/c5-2-1-6-4(9 |
| InChI key | GHASVSINZRGABV-UHFFFAOYSA |
| mp | 282-286 °C (dec.) (lit.) |
| Quality Level | 200  |
| SMILES string | FC1=CNC(=O)NC1=O |
| solubility | 1 M NH4OH: soluble |
| DMSO/DMF: soluble | |
| methanol: soluble | |
| storage temp. | room temp |
| technique(s) | titration: suitable |
| Application: | 5-Fluorouracil has been used to induce apoptosis in cells. It has been used as a chemosensitizing agent. |
| Biochem/physiol Actions: | A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase, thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis. |
| Packaging: | 1, 5, 10 g in glass bottle |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301 - H351 |
| Precautionary statements | P201 - P202 - P264 - P270 - P280 - P301 + P310 |
| Hazard Codes | T |
| Risk Statements | 25-52 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Purity | ≥99% (HPLC) |
| mp | 282-286 °C (dec.) (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12171500 |