Forskolin
SIGMA/F6886 - from Coleus forskohlii, ≥98% (HPLC), powder
Synonym: 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one; Coleonol; Colforsin
CAS Number: 66575-29-9
Empirical Formula (Hill Notation): C22H34O7
Molecular Weight: 410.50
EC Number: 266-410-9
MDL Number: MFCD00082317
Linear Formula: C22H34O7
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F6886-10MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F6886-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F6886-50MG
| assay | ≥98% (HPLC) |
| biological source | Coleus forskohlii |
| color | white to off-white |
| form | powder |
| InChI | 1S/C22H34O7/c1-8-19(5)11- |
| InChI key | OHCQJHSOBUTRHG-KGGHGJDLSA |
| Quality Level | 200  |
| SMILES string | CC(=O)O[C@H]1[C@@H](O)[C@ |
| solubility | ethanol: soluble 50 mg/mL |
| Application: | Forskolin has been used:• for inducing mRNA expression in primary hepatocytes. • as a defatting drug in primary human hepatocytes. • as a medium supplement to induce differentiation of adipose-derived stem cells (ASCs). • in the activation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. • to promote the differentiation of human induced pluripotent stem cells (hiPSCs) into endothelial cells. • to stimulate cystic fibrosis transmembrane conductance regulator (CFTR)-mediated chloride ion secretion in differentiated airway epithelial cells derived from individuals with and without cystic fibrosis (CF). |
| Biochem/physiol Actions: | Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase. |
| Features and Benefits: | This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: | Forskolin, present predominantly in the root of Coleus forskohlii plant, is a potential pharmacological compound. It is used for treating hypertension, respiratory disorders and obesity. Forskolin is a diterpenoid capable of modulating adenylate cyclase enzyme and cyclic adenosine monophosphate (cAMP) levels. Engineering forskolin biosynthetic pathway caters its commercial production for pharmacological use. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. Forskolin promotes differentiation of hepatoma HepaRG cells and activates farnesoid X receptor (FXR) and pregnane X receptor(PXR). |
| General description: | Several studies indicate that forskolin is linked to increased lipolysis, potentially leading to increased fat and weight reduction within the body. The supplementation of forskolin is believed to potentially improve fat loss without losing muscle mass. |
| Packaging: | 10, 25, 50 mg in poly bottle |
| Preparation Note: | Forskolin is soluble in organic solvents such as ethanol, chloroform, and DMSO. |
| Preparation Note: | Forskolin solutions at 5 mg/mL in either ethanol or DMSO are stable for at least 6 months at room temperature per HPLC analysis. |
| Preparation Note: | This product is to be stored in room temperature . Store the product tightly closed under dry condition. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H312 |
| Precautionary statements | P280 - P302 + P352 + P312 - P362 + P364 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 21 |
| Safety Statements | 22-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥98% (HPLC) |
| UNSPSC | 41106305 |