Farnesyl pyrophosphate ammonium salt

SIGMA/F6892 - methanol:ammonia solution, ≥95% (TLC)

Synonym: 3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl pyrophosphate ammonium salt; FPP

CAS Number: 13058-04-3
Empirical Formula (Hill Notation): C₁₅H₃₇N₃O₇P₂
Molecular Weight: 433.42
MDL Number: MFCD00189688
Linear Formula: C₁₅H₃₇N₃O₇P₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-F6892-1VL	1 vial	$119.00 1/EA	Add To Favorites
45-F6892-5VL	5 vials	$409.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (TLC)
form	methanol:ammonia solution
InChI	1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
InChI key	VWFJDQUYCIWHTN-YFVJMOTDSA-N
packaging	vial of 200 μg
Quality Level	100
SMILES string	CC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O
storage temp.	−20°C

Application:	Farnesyl pyrophosphate ammonium salt has been used: • as a prenylation agonist in human osteogenic sarcoma cells in collagen-based cell invasion assays • in the prenylation of the hepatocyte growth factor (HGF) in human umbilical vein endothelial cells (HUVECs) • as a substrate in prenyltransferases assay in diatom Haslea ostrearia
Biochem/physiol Actions:	Farnesyl pyrophosphate (FPP) is the precursor for the biosynthesis of cholesterol, ubiquinone and dolicol. It is part of the intracellular mevalonate pathway. FPP is essential for cell survival and is used for prenylation of several low molecular mass G proteins, including Ras. Inhibition of prenylation results in loss of oncogenic potential of Ras proteins. Inhibition of prenylation may serve as therapeutic potential for management of synaptic plasticity and Alzheimer′s disease.
General description:	Farnesyl pyrophosphate is a 15-carbon isoprenoid synthesized from geranyl pyrophosphate (GPP) by the action of enzyme farnesyl pyrophosphate synthase (FPPS).
Packaging:	1 vial in poly bottle
Packaging:	5 vials in poly bottle
Physical form:	Solution in methanol: 10mM aqueous NH₄OH (7:3) Actual concentration given on label

Symbol	GHS02,GHS06,GHS08
Signal word	Danger
Hazard statements	H225 - H301 + H311 + H331 - H315 - H319 - H370
Precautionary statements	P210 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338
Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25
Safety Statements	16-36/37-45
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	WGK 2
Flash Point(F)	60.8 °F
Flash Point(C)	16 °C

Purity	≥95% (TLC)
Storage Temp.	−20°C
UNSPSC	12352204

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