Fibroblast Growth Factor-8b from mouse
SIGMA/F6926 - >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Synonym: FGF-8b
MDL Number: MFCD01323276
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F6926-25UG
| assay | >97% (SDS-PAGE) |
| biological source | mouse |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| mol wt | calculated mol wt 23.6 kDa |
| predicted mol wt 22 kDa | |
| packaging | pkg of 25 μg |
| potency | 15-60 ng/mL |
| Quality Level | 100  |
| recombinant | expressed in E. coli |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| UniProt accession no. | P37237  |
| Analysis Note: | The biological activity is measured by its ability to stimulate proliferation of NR6R-3T3 fibroblasts. |
| Application: | Fibroblast Growth Factor-8b from mouse has been used- • for subgerminal cavity injection in fertilized quail, chicken, turtle and emu eggs • in the induction of neural differentiation in stem cells from Human Exfoliated Deciduous teeth (SHED) and • in experiments conducted on fertilized hens′ eggs, where FGF8 induced SOX3 gene. |
| Biochem/physiol Actions: | FGF-8b is involved in ectodermal differentiation in the post-gastrulation embryo, including outgrowth and patterning of the face, limbs, and central nervous system. FGF-8b activates the "c" splice form of FGFR-2, FGFR-3, and FGFR-4. |
| Biochem/physiol Actions: | Fibroblast growth factor 8b (FGF8b) isoform of FGF8 has the most potent angiogenic and tumorigenic properties. In prostate cancer, it is responsible for angiogenesis, tumorigenesis and invasion. Exogenous expression of this gene in prostate epithelium leads to prostatic intraepithelial neoplasia (PIN). It also interacts with pattern recognition receptor long pentraxin-3 (PTX3), which is involved in local inflammation. |
| General description: | Fibroblast growth factor 8 (FGF8) is a member of the FGF family, and was initially cloned from androgen-dependent mouse mammary carcinoma cell line. Alternative splicing of this gene produces four different isoforms mainly, FGF8a, FGF8b, FGF8e and FGF8f. |
| Packaging: | 25 μg in glass bottle |
| Physical form: | Lyophilized from a 0.2μm filtered solution in 20mM MOPS, 0.1M sodium sulfate, 0.02% Brij-35, pH 7 containing 50ug of BSA per 1μg as a carrier protein |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >97% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |