FM19G11
SIGMA/F8807 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 329932-55-0
Empirical Formula (Hill Notation): C23H17N3O8
Molecular Weight: 463.40
MDL Number: MFCD01174289
Linear Formula: C23H17N3O8
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | off-white to light brown |
| form | powder |
| InChI | 1S/C23H17N3O8/c1-14-5-7-1 |
| InChI key | XVUOIWIIQVGWAJ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cc1ccc(cc1)C(=O)COC(=O)c2 |
| solubility | DMSO: ≥40 mg/mL |
| storage temp. | 2-8°C |
| Application: | FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α): • to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice • to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells • to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line |
| Biochem/physiol Actions: | FM19G11 is an inhibitor of Hypoxia Inducible Factor α (HIFα), reported to affect self-renewal and differentiation of stem cells. |
| Biochem/physiol Actions: | FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |