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Fatostatin hydrobromide

SIGMA/F8932 - ≥98% (HPLC), powder

Synonym: 25B11 hydrobromide; 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide; Fatostatin A hydrobromide; 2-(2-propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide

CAS Number: 298197-04-3
Empirical Formula (Hill Notation): C18H18N2S·HBr
Molecular Weight: 375.33
MDL Number: MFCD00760867
Linear Formula: C18H18N2S·HBr
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-F8932-5MG 5 mg
 $111.00
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assay ≥98% (HPLC)
color light yellow to yellow
form powder
InChI 1S/C18H18N2S.BrH/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14;/h5-12H,3-4H2,1-2H3;1H
InChI key RJCFNQZVFUMORB-UHFFFAOYSA-N
Quality Level 100 
SMILES string [s]1c(nc(c1)c3ccc(cc3)C)c2cc(ncc2)CCC.Br
solubility DMSO: ≥10 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: Fatostatin hydrobromide has been used:
• to study its anti-cancer activity and effects on mitotic microtubule spindle
• to study its effects on stomatal development
• to prevent SREBP cleavage-activating protein (SCAP)-mediated escort of sterol regulatory element-binding proteins (SREBPs)
Biochem/physiol Actions: Fatostatin hydrobromide is an SREBP inhibitor.
Biochem/physiol Actions: Fatostatin hydrobromide is an SREBP inhibitor. Fatostatin hydrobromide inhibits fat production and lowers glucose levels in mice by inhibiting SREBP (Sterol Regulatory Element Binding Proteins).
General description: Fatostatin is a non-sterol diarylthiazole derivative. It prevents insulin-induced adipogenesis and lowers the amounts of fatty acid, triglyceride and low-density lipoprotein. Fatostatin has anti tumor and antimitotic properties.
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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