Furazolidone
SIGMA/F9505
Synonym: 3-
CAS Number: 67-45-8
Empirical Formula (Hill Notation): C8H7N3O5
Molecular Weight: 225.16
EC Number: 200-653-3
MDL Number: MFCD00010550
Linear Formula: C8H7N3O5
Product Type: Chemical
FT-IR Spectra for 3-(5-Nitrofurfurylideneamino)-2-oxazolidinone.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F9505-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F9505-25G
| antibiotic activity spectrum | Gram-positive bacteria |
| parasites | |
| biological source | synthetic |
| color | yellow |
| form | powder |
| InChI | 1S/C8H7N3O5/c12-8-10(3-4- |
| InChI key | PLHJDBGFXBMTGZ-WEVVVXLNSA |
| mode of action | enzyme | inhibits |
| mp | 256-256 °C |
| Quality Level | 200  |
| SMILES string | [O-][N+](=O)c1ccc(C=NN2 |
| solubility | formic acid: 50 mg/mL |
| Application: | Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes. |
| Biochem/physiol Actions: | Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor and is used as a DNA interstrand cross-linking agent. |
| Packaging: | 10, 25, 100 g in glass bottle |
| Symbol |  GHS08 |
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P281 |
| Hazard Codes | Xn |
| Risk Statements | 62 |
| Safety Statements | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 256-256 °C |
| UNSPSC | 51102829 |