Synonym: 6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 6α,9α-Difluoro-16α-methylprednisolone; 6α-Fluorodexamethasone
CAS Number: 2135-17-3
Empirical Formula (Hill Notation): C22H28F2O5
Molecular Weight: 410.45
EC Number: 218-370-9
MDL Number: MFCD00056464
Linear Formula: C22H28F2O5
Product Type: Chemical
| color |
white to off-white |
| form |
powder |
| InChI |
1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 |
| InChI key |
WXURHACBFYSXBI-GQKYHHCASA-N |
| mode of action |
cell membrane | interferes |
| Quality Level |
200  |
| SMILES string |
[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C |
| solubility |
acetic acid: 10 mg/mL |
| storage temp. |
2-8°C |
| Application: |
Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is commonly used in veterinary practice and has been used in cortisol assays to study early porcine conceptus development. |
| Biochem/physiol Actions: |
Flumethasone is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activation and repressions. The anti-inflammatory actions of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding . |
| Packaging: |
Bottomless glass bottle. Contents are inside inserted fused cone. |
| Symbol |
 GHS08 |
| Signal word |
Warning |
| Hazard statements |
H351 |
| Precautionary statements |
P281 |
| Hazard Codes |
Xn |
| Risk Statements |
40 |
| Safety Statements |
22-36 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Storage Temp. |
2-8°C |
| UNSPSC |
51102829 |
