Fluorescein isothiocyanate–dextran

SIGMA/FD40S - average mol wt 40,000

Synonym: FITC–Dextran

CAS Number: 60842-46-8
MDL Number: MFCD00131092
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-FD40S-100MG	100 mg	$110.00 1/EA	Add To Favorites
45-FD40S-250MG	250 mg	$175.00 1/EA	Add To Favorites
45-FD40S-1G	1 g	$556.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: FD40S-100MG

Properties
Descriptions
Safety Info.
Basic Data

biological source	synthetic (organic)
color	yellow to dark orange
conjugate	FITC conjugate
extent of labeling	0.003-0.020 mol FITC per mol glucose
form	powder
mol wt	average mol wt 40,000
Quality Level	200
solubility	H₂O: soluble 25 mg/mL, clear to slightly hazy, yellow to deep orange
storage temp.	2-8°C

Application:	Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Application:	Fluorescein isothiocyanate–dextran (FITC-dextran, fluorescein-dextran, FITC) was used in the following processes: • Fluorescein-dextran microscopy. • To evaluate the in vivo pulmonary vascular permeability in polymorphonuclear leukocyte α-defensins expressing transgenic mice. • To quantify endocytic activity by flow cytometry. • To label α-lactalbumin and ribonuclease. FITC-dextran is suitable for extensive microcirculation and cell permeability research utilizing microfluorimetry. It is also suitable for the study of plant cell wall porosity and capillary permeability.
General description:	Dextran is a polymer of anhydroglucose. It is composed of approximately 95% α-D-(166) linkages. The remaining (163) linkages account for the branching of dextran. Native dextran has been found to have a molecular weight (MW) in the range of 9 million to 500 million. FITC-dextran has an excitation maximum of 490 nm. It has a pH range of 5 to 9.
Other Notes:	Native dextran has been found to have a molecular weight (MW) in the range of 9 million to 500 million. Lower MW dextrans will exhibit slightly less branching and have a more narrow range of MW distribution. Dextrans with MW greater than 10,000 behave as if they are highly branched. As the MW increases, dextran molecules attain greater symmetry. Dextrans with MW of 2,000 to 10,000, exhibit the properties of an expandable coil. At MW below 2,000, dextran is more rod-like. The MW of dextran is measured by one or more of the following methods: low angle laser light scattering, size exclusion chromatography, copper-complexation and anthrone reagent colorometric reducing-end sugar determination and viscosity.
Other Notes:	Similar to FD-40, but produced by Sigma.
Other Notes:	To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
Packaging:	1 g in poly bottle
Packaging:	100, 250 mg in poly bottle
Preparation Note:	Sigma typically tests the solubility of FITC dextrans in water at concentrations at or above 25 mg/ml. Solutions should be protected from light. In vivo, FITC-dextran is stable for more than 24 hours.

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352201

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