D-(+)-Galactosamine hydrochloride
SIGMA/G0500 - ≥99% (HPLC)
Synonym: 2-Amino-2-deoxy-D-galactopyranose hydrochloride; D-Chondrosamine hydrochloride
CAS Number: 1772-03-8
Empirical Formula (Hill Notation): C6H13NO5 · HCl
Molecular Weight: 215.63
EC Number: 217-198-1
Linear Formula: C6H13NO5 · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: G0500-25G
This image depicts SKU: G0500-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: G0500-5G
This image depicts SKU: G0500-5G
| assay | ≥99% (HPLC) |
| color | white to off-white |
| form | powder |
| impurities | ≤0.5% Glucosamine (HPAE) |
| InChI | 1S/C6H13NO5.ClH/c7-3(1-8) |
| InChI key | CBOJBBMQJBVCMW-NQZVPSPJSA |
| mp | 172-180 °C |
| Quality Level | 200  |
| SMILES string | Cl.N[C@@H](C=O)[C@@H](O)[ |
| solubility | H2O: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow |
| storage temp. | room temp |
| technique(s) | HPLC: suitable |
| Application: | D-(+)-Galactosamine (D-chondrosamine) has been used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research to find new drugs. |
| Application: | D-(+)-Galactosamine hydrochloride has been used: • for the surface binding of mannan-binding lectin (MBL) to modified mica surfaces • in sterile phosphate buffer saline (PBS) before the intraperitoneal injection • in mice for the generation of primary bone marrow-derived macrophages (BMDMs) |
| Biochem/physiol Actions: | Galactosamine (Gal) induces hepatocyte death both by necrosis and apoptosis. It prevents the production of liver RNA via the production of uridine diphosphate hexosamines. D-galactosamine lowers the intracellular pool of uracil nucleotides and thereby prevents the production of RNA and proteins. |
| General description: | D-galactosamine (d-GalN) is a specific hepatotoxic agent metabolized particularly in hepatocytes. It is a 6-carbon amino sugar derived from galactose. |
| Other Notes: | To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page. |
| Packaging: | 10 mg in glass bottle |
| Packaging: | 5, 25 g in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (HPLC) |
| mp | 172-180 °C |
| Storage Temp. | room temp |
| UNSPSC | 12352201 |