Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate

SIGMA/G0635 - ≥85% (HPLC), powder

Synonym: β:γ-Imidoguanosine 5′-triphosphate trisodium salt hydrate; 5′-Guanylyl-imidodiphosphate trisodium salt hydrate; GMP-PNP; Gpp(NH)p

CAS Number: 148892-91-5
Empirical Formula (Hill Notation): C₁₀H₁₄N₆Na₃O₁₃P₃ · xH₂O
Molecular Weight: 588.14 (anhydrous basis)
MDL Number: MFCD00084770
Linear Formula: C₁₀H₁₄N₆Na₃O₁₃P₃ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G0635-5MG	5 mg	$183.00 1/EA	Add To Favorites
45-G0635-25MG	25 mg	$675.00 1/EA	Add To Favorites
45-G0635-100MG	100 mg	$2060.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: G0635-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥85% (HPLC)
biological source	synthetic (organic)
color	white
form	powder
InChI	1S/C10H17N6O13P3.3Na/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22;;;/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1
InChI key	QGJNRMUNXAROIT-CYCLDIHTSA-K
Quality Level	200
	300
shipped in	dry ice
SMILES string	[Na+].[Na+].[Na+].Nc1nc(O)c2ncn([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP(O)([O-])=O)[C@@H](O)[C@H]3O)c2n1
solubility	H₂O: 50 mg/mL
storage temp.	−70°C

Application:	Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate has been used: to study K-RAS interactions with the membrane, for the crystallization of Mycobacterium tuberculosis FtsZ, as a translation initiation inhibitor for the analysis of the 48S pre-initiation complex.
Application:	Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor.
Biochem/physiol Actions:	Guanosine 5′-[ß,γ-imido]triphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.
General description:	Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes.
Packaging:	25, 100 mg in poly bottle
Packaging:	5 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥85% (HPLC)
Storage Temp.	−70°C
UNSPSC	41106305

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