Glybenclamide
SIGMA/G0639 - ≥99% (HPLC)
Synonym: 5-
CAS Number: 10238-21-8
Empirical Formula (Hill Notation): C23H28ClN3O5S
Molecular Weight: 494.00
EC Number: 233-570-6
MDL Number: MFCD00056625
Linear Formula: C23H28ClN3O5S
Product Type: Chemical
| assay | ≥99% (HPLC) |
| InChI | 1S/C23H28ClN3O5S/c1-32-21 |
| InChI key | ZNNLBTZKUZBEKO-UHFFFAOYSA |
| originator | Roche |
| Quality Level | 200  |
| SMILES string | COc1ccc(Cl)cc1C(=O)NCCc2c |
| solubility | DMSO: soluble |
| ethanol: 2 mg/mL | |
| H2O: insoluble | |
| storage temp. | 2-8°C |
| Application: | Glybenclamide has been used: • as a positive control oral hypoglycemic drug to study the hypoglycemic effects of Chlorella in streptozotocin-induced diabetic mice • as a K+ATP channel antagonist in canine with induced acute hypoxia • as an inhibitor of cystic fibrosis transmembrane conductance regulator (CFTR) channel in fetal distal lung epithelial (FDLE) cells |
| Biochem/physiol Actions: | Glybenclamide is a sulfonylurea class of antidiabetic drug used in the treatment of type 2 diabetes mellitus. It has benzamide moiety and stimulates pancreatic β cells to produce insulin resulting in a hypoglycemic effect. It selectively blocks ATP-sensitive K+ channels in the brain with high-affinity binding sites and elicits cardiovascular effects. It may be a potential therapeutic for thromboembolic disorders due to its in vivo antiplatelet functionality. Glybenclamide traverses to the ischemic brain and provides neuroprotection especially during the early stages of stroke. |
| Biochem/physiol Actions: | Selectively blocks ATP-sensitive K+ channels; high affinity binding sites found in brain, pancreatic β cells, and cardiovascular system. |
| Features and Benefits: | This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 5, 10 g in poly bottle |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H370 |
| Precautionary statements | P260 - P264 - P270 - P308 + P311 - P405 - P501 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |