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Guanfacine hydrochloride

SIGMA/G1043 - ≥98% (HPLC)

Synonym: N (Aminoiminomethyl)-2,6-dichlorobenzeneacetamide

CAS Number: 29110-48-3
Empirical Formula (Hill Notation): C9H9Cl2N3O · HCl
Molecular Weight: 282.55
MDL Number: MFCD00798230
Linear Formula: C9H9Cl2N3O · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-G1043-10MG 10 mg
 $69.30
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45-G1043-50MG 50 mg
 $260.00
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assay ≥98% (HPLC)
color white
InChI 1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
InChI key DGFYECXYGUIODH-UHFFFAOYSA-N
originator Promius
Quality Level 100 
SMILES string Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl
solubility H2O: soluble 12 mg/mL at 60 °C
Application: Guanfacine hydrochloride has been used as an α2A adrenoceptor agonist to test its protective effect on hypobaric hypoxia (HH) and in rat brain to measure blood oxygenation level dependent (BOLD) response.
Biochem/physiol Actions: α-2 noradrenergic receptor agonist.
Biochem/physiol Actions: Guanfacine stimulates the brain postsynaptic α2 adrenergic receptor (AR) and mediates the prefrontal cortical (PFC) neuronal regulation and strengthens their network. Guanfacine improves the density of neuronal dendrites and is useful in treating neuropsychiatric disorders. It modulates the synaptic and cytoskeletal proteins expression in prefrontal cortical (PFC) neurons and may improve hypobaric hypoxia (HH) induced PFC dysfunctions. Guanfacine enhances cognitive function and is recommended for attention deficit hyperactivity disorder (ADHD) therapy.
Features and Benefits: This compound was developed by Promius . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352200

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