Glipizide

SIGMA/G117 - solid

Synonym: 1-Cyclohexyl-3-{4-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenylsulfonyl}urea

CAS Number: 29094-61-9
Empirical Formula (Hill Notation): C₂₁H₂₇N₅O₄S
Molecular Weight: 445.54
EC Number: 249-427-6
MDL Number: MFCD00072159
Linear Formula: C₂₁H₂₇N₅O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G117-500MG	500 mg	$120.00 1/EA	Add To Favorites
45-G117-1G	1 g	$213.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: G117-1G

Properties
Descriptions
Safety Info.
Basic Data

color	white
form	solid
InChI	1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
InChI key	ZJJXGWJIGJFDTL-UHFFFAOYSA-N
Quality Level	100
SMILES string	Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
solubility	DMSO: 48 mg/mL
	methanol: 1.9 mg/mL

Application:	Glipizide has been used in: • chick embryo yolk sac membrane (YSM) and chorioallantoic membrane (CAM) assay • MCF-7 breast cancer assay on chorioallantoic membrane (CAM) • metastasis assays • rat aortic ring assay • in vivo matrigel plug assay • 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay • flow cytometry • western blotting
Biochem/physiol Actions:	Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) plays a vital role in potassium balance. It is an ATP-dependent K⁺ channel blocker. The encoded protein is liable for the elimination of potassium in exchange for the absorption of sodium by the epithelial sodium channel (ENaC). Mutation in KCNJ1 is linked with several diseases, such as, antenatal Bartter syndrome and diabetes. Glipizide helps to repress the development of tumors and metastasis by preventing angiogenesis.
General description:	Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) codes for a renal outer medullary potassium channel (ROMK1, Kir1.1). Glipizide is an antidiabetic drug, that is used to treat type II diabetes.(5)
Packaging:	1 g in poly bottle
Packaging:	500 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

12352200

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