Glutathione reduced ethyl ester
SIGMA/G1404 - ≥90% (TLC)
Synonym: γ-Glu-Cys-Gly-OEt; GSH-MEE
CAS Number: 92614-59-0
Empirical Formula (Hill Notation): C12H21N3O6S
Molecular Weight: 335.38
MDL Number: MFCD00156117; MFCD00156117
Linear Formula: C12H21N3O6S
Product Type: Chemical
| assay | ≥90% (TLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C12H21N3O6S/c1-2-21-10 |
| InChI key | JKRODHBGNBKZLE-YUMQZZPRSA |
| Quality Level | 200  |
| SMILES string | CCOC(=O)CNC(=O)[C@H](CS)N |
| storage temp. | −20°C |
| Amino Acid Sequence: | Glu-Cys-Gly-OEt |
| Application: | Glutathione reduced ethyl ester has been used: • to increase intracellular glutathione levels in mouse fibroblast L929 cells • as a medium supplement in Spodoptera frugiperda (Sf)9 cells • to evaluate its effect on lipid peroxidation after spinal cord injury |
| Biochem/physiol Actions: | Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH. It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation. |
| Biochem/physiol Actions: | Glutathione reduced ethyl ester inhibits melanin synthesis by inhibiting tyrosinase activity in Melan-A cells. Its antimelanogenic functionality has potential in treating hyperpigmentation skin disorders. GEE supplementation during islets isolation form pancreas reduces reactive oxygen species production and apoptosis. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (TLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12161504 |