Glucagon

SIGMA/G1774 - ≥95% (HPLC), powder, synthetic

CAS Number: 16941-32-5
Empirical Formula (Hill Notation): C₁₅₃H₂₂₅N₄₃O₄₉S
Molecular Weight: 3482.75
MDL Number: MFCD00167532
Linear Formula: C₁₅₃H₂₂₅N₄₃O₄₉S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G1774-.1MG	0.1 mg	$248.00 1/EA		Add To Favorites
45-G1774-1MG	1 mg	$1220.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
biological source	synthetic
form	powder
InChI	1S/C153H225N43O49S.ClH/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84;/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166);1H/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-;/m0./s1
InChI key	RKGLLHCSSVJTAN-YYICOITRSA-N
Quality Level	300
shipped in	ambient
SMILES string	Cl[H].[H]N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](C(C)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc6c[nH]c7ccccc67)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)O)C(O)=O
solubility	1% acetic acid: 1.00-1.04 mg/mL, clear, colorless
	water: 1.00-1.04 mg/mL, clear, colorless
sterility	non-sterile
storage temp.	−20°C
suitability	suitable for molecular biology
technique(s)	cell based assay: suitable
UniProt accession no.	P01275

Amino Acid Sequence:	His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
Application:	Glucagon (GCG) has been:• used as a component of hormone stock solution for preserving full biological activity of heart tissues obtained from male Sprague-Dawley rats • used as an infusion in phases II and III fasting king penguins to study the various lipolytic, metabolic, and hormonal responses • used for the stimulation of PGC-1α expression in hepatocytes • used to induce the expression of methionine adenosyltransferase α1 (MAT1A), which is involved in the regulation of hepatic levels of S-adenosylmethionine and the adaptive response to fasting • used to study its effect on stimulation of gluconeogenesis through hepatic lipolysis, mediated by inositol trisphosphate receptor 1 (INSP3R1) • intraperitoneally injected in mice to assess glucagon-induced Sam68 subcellular localization in vivo
Biochem/physiol Actions:	Glucagon (GCG) produces elevation in contractility and the frequency of contraction in heart muscles. It activates PI3K (phosphoinositide 3-kinase) and thus, elevates glucose utilization by heart muscles. In multiple mammals, though not humans, this peptide induces lipolysis, and is the major lipolytic hormone in birds. It also induces gluconeogenesis and glycogenolysis in mammals and birds.
Biochem/physiol Actions:	The paired box 6 (PAX6) regulates the expression of glucagon. High levels of glucagon referred to as hyperglucagonemia leads to a high risk of diabetes and is associated with pancreatic neuroendocrine tumors. Defective glucagon hypersecretion is regarded as an etiopathogenic factor.
General description:	Glucagon (GCG) peptide is secreted in response to insulin from pancreatic islets α-cells.
General description:	Glucagon is synthesized from proglucagon and is 29-amino acid peptide hormone. Proglucagon gene is mapped to human chromosome 2q24.2.
Other Notes:	H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl
Other Notes:	Lyophilized from 0.1% TFA in H2O

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.