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GAP-27

SIGMA/G1794 - ≥97% (HPLC)

Synonym: Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile

CAS Number: 198284-64-9
Empirical Formula (Hill Notation): C60H102N15O17
Molecular Weight: 1305.54
MDL Number: MFCD11045577
Linear Formula: C60H102N15O17
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-G1794-2MG 2 mg
 $496.00
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assay ≥97% (HPLC)
biological source human
form powder
InChI 1S/C60H101N15O17/c1-9-31(4)44(54(86)69-41(29-36-19-13-12-14-20-36)52(84)70-45(32(5)10-2)55(87)72-46(59(91)92)33(6)11-3)71-57(89)48(35(8)78)73-51(83)38(21-15-16-26-61)66-50(82)39(24-25-43(79)80)67-56(88)47(34(7)77)74-53(85)42-23-18-28-75(42)58(90)40(22-17-27-65-60(63)64)68-49(81)37(62)30-76/h12-14,19-20,31-35,37-42,44-48,76-78H,9-11,15-18,21-30,61-62H2,1-8H3,(H,66,82)(H,67,88)(H,68,81)(H,69,86)(H,70,84)(H,71,89)(H,72,87)(H,73,83)(H,74,85)(H,79,80)(H,91,92)(H4,63,64,65)/t31-,32-,33-,34+,35+,37-,38-,39-,40-,41-,42-,44-,45-,46-,47-,48-/m0/s1
InChI key SXRAPDIXXYFGJG-MDAHIHQXSA-N
packaging pkg of 2 mg
Quality Level 200 
shipped in ambient
SMILES string N1([C@@H](CCC1)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)O)C(=O)[C@@H](NC(=O)[C@@H](N)CO)CCCNC(=N)N
solubility water: soluble 1.00-1.02 mg/mL, clear, colorless
storage temp. −20°C
technique(s) cell culture | mammalian: suitable
UniProt accession no. P35212 
Amino Acid Sequence: Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile
Application: GAP-27 has been used as a blocking peptide for Cx43 (connexin 43) gap junctions in FDC (follicular dendritic cells)-B cell cultures.
Biochem/physiol Actions: GAP-27 shares homology with a region of extracellular loops of connexins, and hence, is thought to inhibit junctions formed by the connexins Cx32, Cx40 and Cx43. It highly hinders co-operative cell-cell interactions including the synergized beating of embryonic cardiomyocytes. This peptide reduces osteoclastic activity and survival rates. This peptide significantly reduces acetylcholine-mediated hyperpolarization of smooth muscle cells.
Biochem/physiol Actions: Inhibitor of gap junction signaling in endothelial cells.
Packaging: 2 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. −20°C
UNSPSC 12352202

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