α-Glycerophosphate Dehydrogenase-Triosephosphate Isomerase from rabbit muscle

SIGMA/G1881 - Type III, ammonium sulfate suspension

Synonym: GDH/TIM; α-GDH-TPI

MDL Number: MFCD00130488
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G1881-250UN	250 units	$93.10 1/EA		Add To Favorites
45-G1881-1KU	1000 units	$240.00 1/EA		Add To Favorites
45-G1881-5KU	5000 units	$853.00 1/EA		Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

biological source	rabbit muscle
form	ammonium sulfate suspension
GDH activity	75-200 units/mg protein (biuret)
Quality Level	200
storage temp.	2-8°C
TPI activity	750-2000 units/mg protein
type	Type III

Application:	α-glycerophosphate dehydrogenase was used in 2-deoxy-ribose 5-phosphate aldolase (DERA) cleavage (retroaldol) assay.
Application:	α-Glycerophosphate Dehydrogenase-Triosephosphate Isomerase from rabbit muscle has been used in spectrophotometric aldolase assay and fructose 2,6 bisphosphate assay. It has also been used in erythrocyte transketolase (ETK) activity to study the prevalence of and factors associated with thiamin deficiency in obese.
Biochem/physiol Actions:	α-glycerophosphate dehydrogenase catalyzes the conversion of dihydroxyacetone to glycerol phosphate. α-Glycerophosphate dehydrogenase (α-GPDH) has the ability to produce reactive oxygen species (ROS), that is induced by Ca²⁺. Triosephosphate isomerase (TPI) is an essential enzyme in the glycolytic pathway, responsible for converting dihydroxyacetone phosphate (DHAP) into glyceraldehyde-3 phosphate (GAP). TPI′s role is crucial in enhancing the efficiency of the catabolic process within glycolysis. However, a deficiency in TPI can lead to glycolytic enzymopathies, rare genetic disorders characterized by neurologic dysfunction and hemolytic anemia.
Biochem/physiol Actions:	α-Glycerophosphate dehydrogenase (α-GPDH) has the ability to produce reactive oxygen species (ROS), that is induced by Ca²⁺.
General description:	Research area: Neuroscience α-Glycerophosphate Dehydrogenase-Triosephosphate isomerase (α-GDH-TPI or GDH/TIM) is an enzyme mixture of α-glycerophosphate dehydrogenase (GDH) and triosephosphate isomerase (TPI).
Other Notes:	(α-GDH) One unit will convert 1.0 μmole of dihydroxyacetone phosphate to α-glycerophosphate per min at pH 7.4 at 25 °C.
Other Notes:	(TPI) One unit will convert 1.0 μmole of D-glyceraldehyde 3-phosphate to dihydroxyacetone phosphate per min at pH 7.6 at 25 °C.
Packaging:	(Sold on the basis of α-GDH units.)
Physical form:	Mixed crystalline suspension in 3.2 M (NH₄)₂SO₄, with 0.05 g/L EDTA, pH 6.0

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

activity	GDH activity: 75-200 units/mg protein (biuret); TPI activity: 750-2000 units/mg protein
Storage Temp.	2-8°C
Enzyme Commission (EC) Number	1.1.1.8 ( BRENDA \| IUBMB )
UNSPSC	12352204

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