Gö 6983
SIGMA/G1918 - ≥97%
Synonym: 3-
CAS Number: 133053-19-7
Empirical Formula (Hill Notation): C26H26N4O3
Molecular Weight: 442.51
MDL Number: MFCD04040031
Linear Formula: C26H26N4O3
Product Type: Chemical
| assay | ≥97% |
| form | powder |
| InChI | 1S/C26H26N4O3/c1-29(2)11- |
| InChI key | LLJJDLHGZUOMQP-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | COc1ccc2n(CCCN(C)C)cc(C3= |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | −20°C |
| Application: | GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs). |
| Biochem/physiol Actions: | Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC50 = 20 mM). |
| Packaging: | 1 mg in glass bottle |
| Packaging: | 500 μg in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |