Glimepiride

SIGMA/G2295 - ≥98% (HPLC), solid

CAS Number: 93479-97-1
Empirical Formula (Hill Notation): C₂₄H₃₄N₄O₅S
Molecular Weight: 490.62
MDL Number: MFCD00878417
Linear Formula: C₂₄H₃₄N₄O₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G2295-50MG	50 mg	$217.00 1/EA		Add To Favorites
45-G2295-250MG	250 mg	$849.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	solid
InChI	1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-
InChI key	WIGIZIANZCJQQY-RUCARUNLSA-N
mp	212.2-214.5 °C
originator	Sanofi Aventis
Quality Level	100
SMILES string	CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]3CC[C@H](C)CC3)C1=O
solubility	DMSO: >10 mg/mL
storage temp.	room temp

Application:	Glimepiride has been used: • as a hypoglycemic drug to test its anti-diabetic functionality in human umbilical vein cells (HUVECs) • as a sulfonylurea ATP-sensitive potassium channel (K_ATP) channel inhibitor in breast cancer MDA-MB-231 cells • in glucose-stimulated insulin secretion (GSIS) assays of neonatal islet-like cell clusters (NICCs) to test its effect on insulin secretion
Application:	Glimepiride is currently used to treat type 2 diabetes.
Biochem/physiol Actions:	Glimepiride is a potent blocker of cardiac K_ATP channels activated by pinacidil with an IC₅₀ of 6.8 nM.
Biochem/physiol Actions:	Glimepiride reduces blood glucose levels by stimulating the pancreatic β cells to secrete insulin hormone. It interacts with a 65-kD protein associated with β cells.
Biochem/physiol Actions:	Potent blocker of cardiac K_ATP channels.
Features and Benefits:	This compound was developed by Sanofi Aventis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Glimepiride is a class II biopharmaceutical second-generation sulfonylurea.
Packaging:	50, 250 mg in glass bottle

Symbol	GHS08
Signal word	Warning
Hazard statements	H361
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
mp	212.2-214.5 °C
Storage Temp.	room temp
UNSPSC	12352200

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