GDF-15 human
SIGMA/G3046
Synonym: Growth differentiation factor 15; MIC-1; Macrophage inhibitory cyotkine-1
CAS Number: 1821355-80-9
Product Type: Chemical
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| assay | >97% (visualized with silver stain, SDS-PAGE) |
| biological source | human |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| mol wt | dimer 13 kDa (based on N-terminal sequencing, starting at the first histidine of the 6X histidine tag) |
| Quality Level | 100  |
| recombinant | expressed in CHO cells |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | Q99988  |
| Analysis Note: | Under reducing conditions in SDS-PAGE, each recombinant GDF-15 monomer migrates as an ~14 kDa protein. |
| Application: | Growth-differentiation factor-15 (GDF-15) has been associated in the regulation of cell survival, proliferation, and differentiation and also in the protection from ischemia/reperfusion injury. Inflammatory and apoptotic pathways are regulated in injured tissues by GDFs during disease processes. |
| Biochem/physiol Actions: | Although it has been classified as a divergent member of the transforming growth factor-β superfamily, GDF-15 shares structural characteristics with this superfamily. It has been identified as a biomarker for human prostate cancer. Additionally, increased GDF-15 expression has been observed in breast, pancreas and colorectal cancers. Functions of this cytokine include inhibition of TNF-α production, initiation of cartilage formation, and promotion of neuronal survival. It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer. |
| General description: | Growth-differentiation factor-15 (GDF-15) is a stress-responsive member of the transforming growth factor-β cytokine superfamily. It is also known as PTGF-Growth-differentiati |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile, 0.1% trifluoroacetic acid containing 50 μg of bovine serum albumin per 1 μg of GDF-15. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >97% (visualized with silver stain, SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |