Geldanamycin from Streptomyces hygroscopicus

SIGMA/G3381 - ≥98% (HPLC), powder

Synonym: NSC 122750

CAS Number: 30562-34-6
Empirical Formula (Hill Notation): C₂₉H₄₀N₂O₉
Molecular Weight: 560.64
MDL Number: MFCD00274570
Linear Formula: C₂₉H₄₀N₂O₉
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G3381-1MG	1 mg	$780.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	neoplastics
assay	≥98% (HPLC)
color	yellow to orange
form	powder
InChI	1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
InChI key	QTQAWLPCGQOSGP-KSRBKZBZSA-N
mode of action	enzyme \| inhibits
Quality Level	300
SMILES string	CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)C(C)=C[C@H](C)[C@H]1O)C2=O
solubility	DMSO: soluble
sterility	non-sterile
storage temp.	−20°C

Biochem/physiol Actions:	Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Biochem/physiol Actions:	Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	Chemical structure: benzenoid
Packaging:	1 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.