5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate
SIGMA/G3416 - solid, ≥98% (HPLC)
Synonym: GNTI
CAS Number: 219655-57-9 (anhydrous)
Empirical Formula (Hill Notation): C27H29N5O3 · 2C2HF3O2 · xH2O
Molecular Weight: 699.60 (anhydrous basis)
MDL Number: MFCD29923417
Linear Formula: C27H29N5O3 · 2C2HF3O2 · xH2O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| form | solid |
| Quality Level | 100  |
| solubility | H2O: 30 mg/mL |
| storage temp. | 2-8°C |
| Application: | 5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate (GNTI) has been used as a selective κ opioid receptor antagonist: • to study the influence of opioid receptor types on the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitors in inflammation • to study the role of κ opioid receptor in the forebrain-dependent associative task, Whisker-Trace Eyeblink conditioning (WTEB) • to validate its inhibitory actions on Akt kinase activities |
| Biochem/physiol Actions: | 5′-Guanidinonaltrindole di(trifluoroacetate) (GNTI) is a 5‘-guanidine derivative and a selective κ opiate receptor antagonist. It is five-fold more potent and 500-fold more selective than norbinaltorphimine (nor-BNI) for the κ opioid receptor in smooth muscle preparations. |
| Features and Benefits: | This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Legal Information: | Sold under US Patent No. 6,500,824. |
| Packaging: | 5 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |